2000.9 ~ 2006.1 清华大学 研究生(博士)毕业 1996.9 ~ 2000.7 北京大学 本科(学士)

综合运用分子生物学，生物化学，细胞生物学等多种手段，结合基因敲除小鼠模型，研究Wnt信号通路调控机制及其在生理和疾病过程中的作用。主要研究方向：酶类Wnt抑制分子调控Wnt信号的机制；利用基因敲除小鼠模型研究酶类Wnt抑制分子在体内的功能；Wnt通路相关的转化医学研究。

1.Zhang X, He X. Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes, Tiki and Notum. Methods Mol Biol. 2016; 1481: 29-38. 2.Zhang X, Macdonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X. Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. J Biol Chem. 2016 Jan 29; 291(5): 2435-43. 3.Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, Xi He. Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation. Dev Cell. 2015 Mar 23; 32(6): 719-30. 4.Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of b-catenin reveals principles for morphogen receptor-scaffold assemblies. Science. 2013 May 17; 340(6134): 867-70. 5.Zhang X, Abreu JG, Yokota C, Macdonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22; 149(7): 1565-77.