个人简介
教育经历 1990.9 - 1993.7:安化一中,高中毕业。 1993.9 - 1997.7:北京大学,生物化学专业,本科毕业,获理学学士学位。 1997.9 - 2002.7:北京大学,生物化学专业,研究生毕业,获理学博士学位。 工作经历 2007.10 - 2008.9:凯斯西储大学医学院,Department of Physiology and Biophysics,担任 Senior Research Associate(高级研究助理)。 2008.9 - 2009.6:凯斯西储大学医学院,Department of Biophysics and Physiology,担任 Instructor(讲师)。 2008.12 - 2015.10:华中科技大学,生命科学与技术学院,担任副教授。 2015.11 - 至今:华中科技大学,生命科学与技术学院,担任教授。
研究领域
本课题组主要从事酸碱离子跨膜运输的生物物理学、生理及病理学研究,主要包括: (1)酸碱转运体蛋白的结构与功能 (2)酸碱转运体的功能调控机制 (3)酸碱转运体在中枢神经系统、消化系统、泌尿与生殖等系统中的生理学作用 (4)酸碱平衡调控与各种疾病的关系,包括神经系统疾病、代谢性酸中毒、肿瘤及不孕不育等。
近期论文
[1]Ying Liu, Deng-Ke Wang,Li-Ming Chen*.The physiology of bicarbonate transporters in mammalian reproduction.Biology of Reproduction,(4):99, 1-13 [2]1. Li-Ming Chen, Mei Liu, Ying Liu*. Electrophysiology principles of Na+/HCO3– cotransporters. Acta Physiologica Sinica. 2016, 68(3): 323-334. DOI: 10.13294/j.aps.2016.0036 (Review article in Chinese). [3]Han WU,Shiyong LIU,Pan SU,Zhang-Dong XIE,Tian-Xiang GUI,Lei ZHAO.Ying LIU,Li-Ming CHEN.Molecular insight into coordination sites for substrates and their coupling kinetics in Na+/HCO3- cotransporter NBCe1.The Journal of Physiology,2022, [4]Pan SU,Han WU,Meng WANG,Lu CAI.Ying LIU,Li-Ming CHEN.IRBIT activates NBCe1-B by releasing the auto-inhibition module from the transmembrane domain.[J].The Journal of Physiology,2021, [5]Jin-Lin Wang#, Xiao-Yu Wang#, Deng-Ke Wang, Mark D. Parker, Raif Musa-Aziz, Jacob Popple, Yi-Min Guo, Tian-Xin Min, Tian Xia, Min Tan, Ying Liu, Walter F. Boron, Li-Ming Chen..Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL..[J].The Journal of Physiology,2020,(16):3395-3415 (封面论文) [6]Meng Wang#, Han Wu#, Ying Liu*, Li-Ming Chen*..Activation of mouse NBCe1-B by Xenopus laevis and mouse IRBITs: role of the variable Nt appendage of IRBITs..BBA-Biomembranes,2020,(6): [7]Jin-Lin Wang#, Lei Zhao#, Jun Zhu, Deng-Ke Wang, Mei-Juan Ren, Meng Wang, Ying Liu*, Walter F. Boron, Li-Ming Chen*.Expression, localization, and effect of high salt intake on electroneutral Na+/HCO3– cotransporter NBCn2 in rat small intestine: implication in intestinal NaCl absorption..[J].Frontiers in Physiology,2019,(10):1334