学习经历 1998-09—2002-06，南开大学，生物化学，理学学士 2002-09—2007-07，中科院化学所，化学，博士 工作经历 2008.08-2008.06 湖南大学化学化工学院，讲师 2008.06-2010.12 湖南大学化学化工学院，副教授 2011.01-至今 湖南大学化学化工学院，教授 2011.11-2012.11 Purdue University，公派博士后 2015.11-2019.10 湖南大学化学化工学院副院长 2019.10-至今 湖南大学研究生院副院长兼学位办主任

生命分析化学、化学生物学

S. Yang, M. Wang, D. Tian, X. Zhang, K. Cui, S. Lü, H.-H. Wang, M. Long, Z. Nie*. DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling. Nat. Chem. Biol., 2024, 20, 1066. K. Wang, S. Liu, S. Zhou, A. Qileng, D. Wang, Y. Liu, C. Chen, C. Lei*, Z. Nie*. Ligand-responsive artificial protein-protein communication for field-deployable cell-free biosensing. Angew. Chem. Int. Ed., 2024, e202416671 (Very Important Paper) X. Xie , H. Nan, J. Peng, K. Zeng, H.-H. Wang*, Y. Huang*, Z. Nie*. Hydrogen Sulfide-Triggered Artificial DNAzyme Switches for Precise Manipulation of Cellular Functions. Angew. Chem. Int. Ed., 2024, 63, e202410380. (Very Important Paper) W. Kang, F. Xiao, X. Zhu, X. Ling, S. Xie, R. Li, P. Yu, L. Cao, C. Lei*, Y. Qiu, T. Liu, Z. Nie*. Engineering anti-CRISPR proteins to create CRISPR-Cas protein switches for activatable genome editing and viral protease detection. Angew. Chem. Int. Ed., 2024, 63, e20240599. F. He, M. Wang, J. Wang, H-.H. Wang, Z. Nie*. An extracellular miRNA-responsive artificial receptor via dynamic DNA nano-assembly for biomarker-driven therapy. Angew. Chem. Int. Ed., 2023, 62, e202305227. (Very Important Paper) R. Tang, Y. Fu, B. Gong, Y.-Y. Fang, H.-H. Wang, Y. Huang, Z. Nie*. P. Wei*. A chimeric conjugate of antibody and programmable DNA nanoassembly smartly activates T cells for precise cancer cell targeting. Angew. Chem. Int. Ed., 2022, 61, e202205902. M. Wang, D. Yang, Q Lu, L. Liu, Z. Cai, Y. Wang, H.-H. Wang, P. Wang*, Z. Nie*. Spatially reprogramed receptor organization to switch cell behavior using a DNA origami-templated aptamer nanoarray. Nano Lett., 2022, 22, 8445-8454. J. Zhang, H. Li, B. Lin, X. Luo, P. Yin, T. Yi, B. Xue, X.-L. Zhang, H. Zhu, Z. Nie*. Development of near-infrared nucleic acid mimics of fluorescent proteins for in vivo imaging of viral RNA with turn-on fluorescence. J. Am. Chem. Soc., 2021, 143, 19317-19329. K. Shi, S. Xie, R. Tian, S. Wang, Q. Lu, D. Gao, C. Lei, H. Zhu, Z. Nie*. A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics. Science Advances, 2021, 7, eabc7802. H. Li, J. Gao, L. Cao, X. Xie, J. Fan, H. Wang, H.-H. Wang*, Z. Nie*. A DNA molecular robot that autonomously walks on the cell membrane to drive cell motility. Angew. Chem. Int. Ed., 2021, 60, 26087-26095. (Very Important Paper, Inside Back Cover) J. Zhang, Z. Qiu, J. Fan, F. He, W. Kang, S. Yang, H.-H. Wang*, J. Huang*, Z. Nie*. Scan and Unlock: A programmable DNA molecular automaton for cell-selective activation ligand-based signaling. Angew. Chem. Int. Ed., 2021, 60, 6733-6743. (Hot Paper) X. Zhu, R. Tang, S Wang, X. Chen, J. Hu, C. Lei, Y. Huang, H. Wang, Z. Nie*, S. Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence and magnetic resonance bimodal imaging capabilities, ACS Nano, 2020, 14, 2172-2182. X. Luo, B. Xue, G. Feng, J. Zhang, B. Lin, P. Zeng, H. Li, H. Yi, X.-L. Zhang, H. Zhu*, Z. Nie*.Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191. G. Feng, X. Luo, X. Lu, S. Xie, L. Deng, W. Kang, F. He, J. Zhang, C. Lei*, B, Lin, Y. Huang, Z. Nie*, S. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment.Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (Very Important Paper, Back Cover) M. Wang, F. He, H. Li, S.H. Yang, J. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. Near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613. H. Li, M. Wang, T. Shi, S. Yang, J. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic engineering of receptor to control cell behavior. Angew. Chem. Int. Ed., 2018, 57,10226-10230. (Hot paper) Y. Li, S. Sun, L. Fan, S. Hu, Y. Huang, K. Zhang, Z. Nie*, S. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis.Angew. Chem. Int. Ed., 2017, 56, 14888-14892. Z. Nie*, P. Wang, C. Tian, C. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405. C. Lei, Y. Huang, Z. Nie*, J. Hu, L. Li, G. Lu, Y. Han, S. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362.