个人信息：

男，1979年8月出生，博士，博士生导师，九三学社社员，河南大学黄河学者特聘教授，主要从事肿瘤分子标志物和液体活检技术开发等方面的研究。已在国际主流期刊上总共发表SCI论文30多篇，其中包括Gastroenterology,InternationalJournalofCancer,EuropeanJournalofCancer,Carcinogenesis,LiverInternational,ScientificReports,MolecularCancer和CancerScience等，当前总被引500多次，h-index为13，i10-index为17。

受教育经历

2003/09-2006/07，中国科学院昆明动物所，博士

2000/09-2003/07，江西农业大学动物科技学院，硕士

1996/09-2003/07，江西农业大学动物科技学院，学士

研究工作经历

2013/09-至今河南大学药学院，教授

2013/07-2013/09第四军医大学基础部教学与实验中心，合作研究

2010/07-2013/07美国托马斯杰斐逊大学Kimmel癌症研究中心，博士后

2008/08-2010/06美国托马斯杰斐逊大学药理系，博士后

2006/09-2008/07美国美国俄亥俄州立大学癌症研究中心，博士后

主持承担的主要科研项目（总计在研经费456万元）：

国家自然科学基金NSFC-河南省联合项目，基金号：U1604167；项目名称：游离线粒体IMOs作为肝癌液体活检标志物的临床应用及功能研究；资助金额：46万元；起止时间：2017.1-2019.12；主持人（在研）

河南省高校科技创新人才支持计划,计划编号：15HASTIT035；研究方向：无创分子标志物的发掘及其转化医学研究；资助经费：60万元；资助期限：2015.1-2017.12；主持人（在研）

河南大学杰出青年科研人才培育计划，资助金额：300万元，起止时间：2014.8-2019.7；主持人（在研）

河南大学黄河学者启动基金，资助金额：50万元，起止时间：2013.11-2017.10；主持人（在研）

国家自然科学基金青年项目，基金号:81201578；项目名称：缺锌诱导的DNA异常甲基化在食管鳞状上皮细胞癌变过程中的机理研究；资助金额:23万元；起止时间:2013.1-2015.12；主持人(已结题)

基因检测与个体化临床用药（PCR-basedgenedetectionandtailoredpatienttreatment)

游离核酸与液体活检（Circulatingcell-freenucleicacidsandliquidbiopsy）

线粒体DNA生物学及其免疫功能(MitochondrialDNAanditsimmunefunctions)

欢迎对肿瘤分子标志物以及体外诊断行业有兴趣的广大同学加入我们的科研团队！

第一作者及通讯作者SCI论文

[1]WanS,HannHW,LaiY,HannRS,YeZ,WangC,LiL,MyersRE,LiB,XingJ,YangY.ProspectiveandlongitudinalevaluationsoftelomerelengthofcirculatingDNAasariskpredictorofhepatocellularcarcinomainHBVpatients.Carcinogenesis.2017Apr;38(4):439-446.(IF=4.87,SCI二区)

[2]BaoD,BaY,ZhouF,ZhaoJ,YangQ,GeN,GuoX,WuZ,ZhangH,WanS*,XingJ*.AlterationsoftelomerelengthandmtDNAcopynumberareassociatedwithoverallsurvivalinhepatocellularcarcinomapatientstreatedwithtransarterialchemoembolization.CancerChemotherapyandPharmacology.2016Aug;DOI:10.1007/s00280-016-3128-1.(通讯作者)(IF=2.824,SCI三区)

[3]LiL,HannHW,WanS,HannR,WangC,LaiY,YeX,EvansA,MyersR,YeZ,LiB,XingJ,YangH*.Cell-freecirculatingmitochondrialDNAcontentandriskofhepatocellularcarcinomainpatientswithchronicHBVinfection.ScientificReports.2016Apr;6:23992.(共同第一作者）(IF=5.58,SCI二区)

[4]DongG,HeX,ChenY,CaoH,WangJ,LiuX,WangS,WanS*,XingJ*.Geneticvariationsingenesofmetabolicenzymespredictpostoperationalprognosisofpatientswithcolorectalcancer.MolecularCancer.2015Sep;17(14):171.(*通讯作者)(IF=4.257,SCI二区)

[5]WanS,WuY,ZhouX,ChenY,AnJ,YuX,ZhangH,YangH*,XingJ*.Polymorphismsingenesoftricarboxylicacidcyclekeyenzymesareassociatedwithearlyrecurrenceofhepatocellularcarcinoma.PLoSOne.2015Apr;10(4):e0124471.(IF=3.234,SCI三区)

[6]DongH,BaoD,GuoX,HuJ,LiX,WanS*,XingJ*.Effectofthymidylatesynthasegenepolymorphismontheresponsetochemotherapyandclinicaloutcomeofnon-smallcelllungcancerpatients.TumorBiology.2015Apr;36(9),7151-7157.(*通讯作者)(IF=3.611,SCI三区)

[7]WuYS,BaoDK,DaiJY,ChenC,ZhangHX,YangYF,XingJL,HuangXJ*,WanSG*.PolymorphismsingenesoftheDeNovolipogenesispathwayandoverallsurvivalofhepatocellularcarcinomapatientsundergoingtransarterialchemoembolization.AsianPacificJournalofCancerPrevention.2015Mar;16(3):1051-1056.(*通讯作者)(IF=2.514,SCI四区)

[8]HannHW,WanS,LaiY,HannRS,MyersRE,PatelF,ZhangK,YeZ,WangC,YangH*.ASTtoplateletratioindexasaprospectivepredictorofhepatocellularcarcinomariskinpatientswithchronicHBVinfection.JournalofGastroenterologyandHepatology.2015Jan;30(1):131-8.(共同第一作者)(IF=3.504，SCI三区)

[9]DuX,WanS,ChenY,QuP,HuangX,YuX,YangH,ZhangY*,XingJ*.Geneticvariantsingenesoftricarboxylicacidcyclekeyenzymespredictpostsurgicaloverallsurvivalofpatientswithhepatocellularcarcinoma.AnnalsofSurgicalOncology.2014Dec;21(13):4300-7.(共同第一者)(IF=3.93，SCI二区)

[10]YangY,FeiF,SongY,LiX,ZhangZ,FeiZ,SuH*,WanS*.PolymorphismsofEpCAMGeneandPrognosisofnon-smallcelllungcancerinHanChinese.CancerScience.2014Jan;105:89-96.(*通讯作者)(IF=3.523，SCI二区)

[11]WanS.LaiY,MyersRE,LiB,PalazzoJP,BurkartAL,ChenG,XingJL,YangH*.Post-diagnosishemoglobinchangeassociateswiththeoverallsurvivalofmultiplemalignancies-Resultsfroma14-yearhospital-basedcohortoflung,breast,colorectal,andlivercancers.BMCCancer.2013Jul10;13:340.(IF=3.362，SCI三区)

[12]WanS,LaiY,MyersRE,LiB,HyslopT,LondonJ,ChatterjeeD,PalazzoJP,BurkartAL,ZhangK,XingJ,YangH*.Preoperativeplateletcountassociateswithsurvivalanddistantmetastasisinsurgicallyresectedcolorectalcancerpatients.JournalofGastrointestinalCancer.2013Sep;44(3):293-304.

[13]WanS,HannHW,MyersR,FuX,HannH,KimSH,TangH,XingJ,YangH*.TelomerelengthincirculatingserumDNAasanovelnon-invasivebiomarkerforcirrhosisrisk:anestedcasecontrolanalysis.LiverInternational.2012Sep;32(8):1233-41.(IF=4.85，SCI二区)

[14]FuX,WanS,HannHW,MyersR,HannRS,AuJ,ChenB,XingJ,YangH*.Relativetelomerelength:anovelnon-invasivebiomarkerfortheriskofnon-cirrhotichepatocellularcarcinomainHBVpatients.EuropeanJournalofCancer.2012May;48(7):1014-22(共同第一者).(IF=5.417，SCI二区)

[15]HannHW,WanS,MyersR,HannRS,XingJ,ChenB,YangH*.ComprehensiveanalysisofcommonserumliverenzymesasprospectivepredictorsofhepatocellularcarcinomainHBVpatients-resultsofaclinic-basedcohort.PLoSOne.2012;7(10):e47687.(共同第一作者).(IF=3.234，SCI三区)

[16]WanS,CivanJ,RossiS,YangH*.ProfilingHBVintegrationsinhepatocellularcarcinoma.HepatobiliarySurgeryandNutrition.2012Oct;1:19.(Invitedcommentary)

[17]WanSG,TaccioliC,JiangY,ChenH,SmalleyKJ,HuangK,LiuXP,FarberJL,CroceCM,FongLY*.ZincdeficiencyactivatesS100A8inflammationintheabsenceofCOX-2andpromotesmurineoral-esophagealtumorprogression.InternationalJournalofCancer.2011Jul15;129(2):331-45.(IF=5.085，SCI二区)

[18]WanSG,JinY,LeeWH,ZhangY*.AsnakevenommetalloproteinasethatinhibitedcellproliferationandinducedmorphologicalchangesofECV304cells.Toxicon.2006,47(4):480-489.(IF=2.492，SCI三区)

[19]WanSG,JinY,LeeWH,ZhangY*.CloningofTwoNovelP-IIIClassMetalloproteinasesfromTrimeresurusstejnegeriVenomGland.Toxicon.2006,47(4):465-472.(IF=2.492，SCI三区)

共同作者的SCI论文

[20]TaccioliC,WanSG,LiuCG,AlderH,VoliniaS,FarberJL,CroceCMandFongLYY.ZincreplenishmentreversesoverexpressionoftheproinflammatorymediatorS100A8andesophagealpreneoplasiaintherat.Gastroenterology.2009,136(3):953-66.(IF=16.716，SCI一区)

[21]XingJ,WanS,ZhouF,QuF,LiB,MyersRE,FuX,PalazzoJP,HeX,ChenZ,YangH.GeneticPolymorphismsinPre-microRNAGenesasPrognosticMarkersofColorectalCancer.CancerEpidemiology,Biomarkers&Prevention.2012Jan21(1):217-27.(IF=4.125，SCI二区)

[22]DaiJ,WanS,ZhouF,MyersR,GuoX,FuX,PalazzoJ,DouK,YangH,XingJ.GeneticpolymorphisminaVEGF-independentangiogenisisgeneANGPT1andoverallsurvivalofcolorectalcancerpatientsaftersurgicalresection.PLoSOne.2012;7(4):e34758.(IF=3.234，SCI二区)

[23]DongG,GuoX,FuX,WanS,ZhouF,MyersR,BaoG,BurkartA,YangH,XingJ.PotentiallyfunctionalgeneticvariantsinKDRgeneasprognosticmarkersinpatientswithresectedcolorectalcancer.CancerScience.2012Mar;103(3):561-8.(IF=3.523，SCI二区)

[24]YuanP,WangS,ZhouF,WanS,YangY,HuangX,ZhangZ,ZhuY,ZhangH,XingJ.FunctionalpolymorphismsinNPAS2geneareassociatedwithoverallsurvivalinTACE-treatedhepatocellularcarcinomapatients.CancerScience.2014Apr;105(7):825-32.(IF=3.523，SCI二区)

[25]WangC,HannHW,HannRS,WanS,MyersRE,YeZ,XingJ,YangH.CirculatingMitochondrialDNAContentAssociatedwiththeRiskofLiverCirrhosis:ANestedCase-ControlStudy.DigestiveDiseasesSciences.2015Jan;60(6):1707-15.(IF=2.613，SCI四区)

[26]ChenY,QuF,HeX,BaoX,LiuX,WanS,XingJ.Shortleukocytetelomerelengthpredictspoorprognosisandindicatesalteredimmunefunctionsincolorectalcancerpatients.AnnalsofOncology,2014Apr.25(4):869-876.(IF=7.04，SCI二区)

[27]YuX,GeN,GuoX,ShenS,LiangJ,HuangX,WanS,XingJ,HuangQ,YangY.Geneticvariantsintheepcamgeneisassociatedwiththeprognosisoftransarterialchemoembolizationtreatedhepatocellularcarcinomawithportalveintumorthrombus.PLoSOne.2014Apr9;9(4):e93416.(IF=3.234，SCI二区)

[28]LiuB,LiuQ,SongY,LiX,WangY,WanS,ZhangZ,SuH.PolymorphismsofHIF1Ageneareassociatedwithprognosisofearlystagenon-small-celllungcancerpatientsaftersurgery.MedicalOncology.2014Apr;31(4):877.(IF=2.634，SCI四区)

[29]WangS,ChenY,QuF,HeS,HuangX,JiangH,JinT,WanS,XingJ.Associationbetweenleukocytetelomerelengthandgliomarisk:acase-controlstudy.Neuro-Oncology.2013Dec22.(IF=5.562，SCI二区)

[30]HannHW,FuX,MyersRE,HannRS,WanS,KimSH,AuN,XingJ,YangH.Predictivevalueofalphafetoproteininthelong-termriskofdevelopinghepatocellularcarcinomainpatientswithhepatitisBvirusinfection-resultsfromaclinic-basedlongitudinalcohort.EuropeanJournalofCancer.2012Mar;(IF=5.417，SCI二区)

[31]LeiW,HuangY,ZhangY,YuG,WanS,LeeW,ZhangY.ThefrogtrefoilfactorBm-TFF2activateshumanplateletsviaGqandG12/13signalingpathway.Toxicon.2012Jan;59(1):104-9.(IF=2.492，SCI三区)

[32]XingJ,MyersRE,HeX,QuF,ZhouF,MaX,HyslopT,BaoG,WanS,YangH,ChenZ.GWAS-identifiedcolorectalcancersusceptibilitylocusassociateswithdiseaseprognosis.EuropeanJournalofCancer.2011Jul47(11):1699-707.(IF=5.417，SCI二区)

[33]ZhangJ,ZhangY,WanSG,WeiSS,LeeWH,ZhangY.Bm-TFF2,atrefoilfactorproteinwithplateletactivationactivityfromfrogBombinamaximaskinsecretions.BiochemicalandBiophysicalResearchCommunications.2005,330:1027–1033.(IF=2.297，SCI四区)