方东
博士 硕士生导师 副教授
个人简介
受教育经历(EducationalExperience)：
2010/09-2014/06，北京大学，基础医学院，博士
2007/09-2010/06，郑州大学，基础医学院，硕士
2003/09-2007/06，河南大学，药学院，学士。
工作经历(ProfessionalExperience)：
2019/01–至今，河南大学，药学院，副教授；
2015/04–2018/12，河南大学，药学院，讲师；
承担项目情况(FinancialSupports)
[1]Wnt5b介导P2X3受体上膜的机制及其在骨癌痛中的作用研究，81701110，20万，2018.01-2020.12，国家自然科学基金项目，主持人。
[2]嘌呤能P2X3受体上膜的机制及其在骨癌痛中的作用研究，10万，2018.12-至今，河南省博士后项目一等资助，主持人。
[3]多胺通过蛋白激酶AKT促进肝癌转移，2万，2016.01.01-2017.12，河南省教育厅科学技术研究重点项目，主持人。
研究领域
癌及癌症痛的发病机制。
近期论文
[1]DongFang,Ling-YuKong,CaiJie,Ji-ShengHan,Guo-GangXing.IL-6-mediatedfunctionalupregulationofTRPV1receptorsinDRGneuronsviaactivationofJAK/PI3Ksignalingpathway:rolesinthedevelopmentofbonecancerpaininaratmodel,Pain,2015,156(6):1124-1144.(IF=6.02)
[2]CongWang,PingRuan,YingZhao,XiaominLi,JunWang,XiaoxiaoWu,TongLiu,ShashaWang,JiuzhouHou,WeiLi,QianLi,JinghuaLi,FujunDai,DongFang*,ChaojieWang*,SongqiangXie*.Spermidine/spermineN1-acetyltransferaseregulatescellgrowthandmetastasisviaAKT/β-cateninsignalingpathwaysinhepatocellularandcolorectalcarcinomacells；Oncotarget；2017，8(1):1092-1109.(IF=5.08)
[3]WeiLi,Jiu-ZhouHou,JieNiu,Zhuo-QingXi,ChangMa,HuaSun,Chao-JieWang,DongFang*,QinLi*,Song-qiangXie*..Akt1inhibitionpromotesbreastcancermetastasisthroughEGFR-mediatedβ-cateninnuclearaccumulation；CellCommunicationandSignaling,2018,16(1):82.(IF=5.3)
[4]JieNiu,XiaoMengLi,XiaoWang,ChaoLiang,YiDanZhang,HaiYingLi,FanYeLiu,HuaSun，SongQiangXie,DongFang*.DKK1inhibitsbreastcancercellmigrationandinvasionthroughsuppressionofβ-catenin/MMP7signalingpathway；CancerCellInternational；2019,19:168.[IF=3.36]
[5]YingZhao,Chao-ChaoGe,JunWang,Xiao-XiaoWu,Xiao-MinLi,WeiLi,Sha-ShaWang,TongLiu,Jiu-ZhouHou,HuaSun,DongFang*,Song-QiangXie*.MEKinhibitor,PD98059,promotesbreastcancercellmigrationbyinducingβ-cateninnuclearaccumulation；OncologyReports;2017,38(5):3055-3063.[IF=3.06]
[6]Jiu-ZhouHou,Zhuo-QingXi,JieNiu,WeiLi,XiaoWang,ChaoLiang,HuaSun,DongFang*,Song-qiangXie*.InhibitionofPIKfyveusingYM201636suppressesthegrowthoflivercancerviatheinductionofautophagy；OncologyReports,2018,41(3):1971-1979.[IF=3.06]
[7]JieNiu,XiaoWang,ChaoLiang,Yi‐DanZhang,Fan‐YeLiu,Hai‐YingLi,Song‐QiangXie,HuaSun,DongFang*.Suppressionofepidermalgrowthfactorreceptor‐mediatedβ‐cateninnuclearaccumulationenhancestheanti‐tumoractivityofphosphoinositide3‐kinaseinhibitorinbreastcancer；CellBiologyInternational；2019,43(8):931-939.2017;18:2231-2246..[IF=2.12]
[8]YingWang,Chen-YangFeng,Hao-YingHe,Jin-JinHe,JunWang,Xiao-MinLi,Sha-ShaWang,WeiLi,Jiu-ZhouHou,TongLiu,DongFang*,Song-QiangXie*.SensitizationofTRPV1receptorsbyTNF-αorchestratesthedevelopmentofvincristine-inducedpain.2018,OncologyLetters,15(4):5013-5019.[IF=1.87]