个人信息（Personals）：

男，1973年1月生，博士，硕士生导师，教授，黄河学者特聘教授。DrugDiscoveries&Therapeutics编委，河南省药学会药物制剂专委会副主任委员，河南省药效物质基础国际联合实验室副主任，河南省核蛋白基因调控国际联合实验室常务副主任，河南省开封市药学会常务理事、技术部主任，河南大学创新药物设计与评价研究所所长。

受教育经历(EducationalExperience)：

2002/09-2007/10，美国新墨西哥州立大学，化学，博士

1998/09-2000/12，华东理工大学，精细化工研究所，攻读博士

1995/09-1998/04，南京理工大学，化工学院，硕士

1991/09-1995/06，南京理工大学，化工学院，学士

工作经历(ProfessionalExperience)：

2015/09–至今，河南大学，药学院，教授；

2007/11–2015/08，美国堪萨斯大学，化学系/药学院，博士后/研究员；

2001/01–2001/05；药明康德，研发工程师

承担项目情况(FinancialSupports)

[1]河南大学黄河学者启动基金，50万元，2015.09-2020.08，河南省博士后科研项目，主持。

专利（Patents）：

[1]Hu,Yurong;Ji,Mengfei;Li,Huili;Yuan,Jinxiu;Duan,Shaofeng;Xu,Xin;Huang,ShengnanTestkitdetectionmethodandapplicationforearlydiagnosisoftumordiseases.CN107893101A20180410）

[2]张国瑜，李涛，吴东栋，赵琼，腾铁山，段少峰，姬新颖.一种基于干细胞源外泌体的组合物及其在制备治疗心肌梗死的药物中的应用.(201710286101.3-2017-06-05)

[3]Hu,Yurong;Niu,Zhenxi;Chen,Jie;Zhang,Ningxia;Yao,Xing;Duan,Shaofeng;Huang,Shengnan;Zhang,Junxia;Wang,Weiping;Liu,YingetalFromFamingZhuanliShenqing.Amethodforpreparingamphiphilicpolymerandapplicationthereof.(CN106432607A-2017-02-22)

[4]Forrest,MarcusLaird,Zhang,Ti,Senadheera,S.P.SanjeewaN.,Aires,Daniel,Zhao,Yunqi,Duan,Shaofeng,Groer,Chad.TARGETEDMTORINHIBITOR(US20160279108(A1)-2016-09-29)

[5]M.LairdForrest*,ShaofengDuan,Shuang,Cai,TiZhang,QiuhongYang.Drugandimagingagentdeliverycompositionsandmethods.(WO2013109907(A1)-2013-07-25)

1）小分子抗癌药的设计与合成；2）纳米高分子药物载体的设计与合成；3）抗癌前药的合成及药物控释。

[1]Dong,Qian;Yang,Bo;Han,Ju-Guo;Zhang,Meng-Meng;Liu,Wei;Zhang,Xin;Yu,Hai-Lan;Liu,Zheng-Guo;Zhang,Shi-Hui;Li,Tao;Dong‐DongWu*;Xin-YingJi*；Shao-FengDuan*Anovelhydrogensulfide-releasingdonor,HA-ADT,suppressesthegrowthofhumanbreastcancercellsthroughinhibitingthePI3K/AKT/mTORandRas/Raf/MEK/ERKsignalingpathways.CancerLetters2019,455,60-72

[2]Yan,Li-Juan;Guo,Xin-Hong;Wang,Wei-Ping;Hu,Yu-Rong*;Duan,Shao-Feng*;Liu,Ying;Sun,Zhi;Huang,Sheng-Nan;Li,Hui-li.GeneTherapyandPhotothermalTherapyofLayer-by-LayerAssembledAuNCs/PEI/miRNA/HANanocomplexes.CurrentCancerDrugTargets2019,19(4),330-337

[3]Dong-DongWu,Da-YongWang,Hui-MinLiJian-ChengGuo,Shao-FengDuan*,Xin-YingJi*.Hydrogensulfideasanovelregulatoryfactorinliverhealthanddisease.OxidativeMedicineandCellularLongevity2019,1-16

[4]Dong‐DongWu,Shi‐YuLiu,Ying‐RanGao,DanLu,YaHong,Ya‐GeChen,Peng‐ZhenDong,Da‐YongWang,TaoLi,Hui‐MinLi,Zhi‐GuangRen,Jian‐ChengGuo,FeiHe,Xue‐QunRen,Shi-YongSun,Shao‐FengDuan*,Xin‐YingJi*.Tumournecrosisfactor‐α‐inducedprotein8‐like2isanovelregulatorofproliferation,migration,andinvasioninhumanrectaladenocarcinomacells.JCellMolMed.2019,23(3),1698-1713

[5]Li,Huili;Li,Huanjie;Yu,Wei;Huang,Shengnan;Liu,Ying;Zhang,Ningxia;Yuan,Jinxiu;Xu,Xin;Duan,Shaofeng*;Hu,Yurong*.PEGylatedhyaluronidase/NIRinduceddrugcontrolledreleasesystemforsynergeticchemo-photothermaltherapyofhepatocellularcarcinoma.EuropeanJournalofPharmaceuticalSciences2019,133,127-136

[6]CuiLi,ChenZang,QixiaNie,BoYang,BaoxianZhang,ShaofengDuan*.Simultaneousdeterminationofsevenflavonoids,twophenolicacidsandtwocholesterinesinTanreqinginjectionbyUHPLC-MS/MS.JournalofPharmaceuticalandBiomedicalAnalysis2019,163,105–112.

[7]Wang,Weiping;Huang,Shengnan;Yuan,Jinxiu;Xu,Xin;Li,Huili;Lv,Zhanwei;Yu,Wei;Duan,Shaofeng*;Hu,Yurong*.ReversemultidrugresistanceinhumanHepG2/ADRbyanti-miR-21combinedwithhyperthermiamediatedbyfunctionalizedgoldnanocages.MolecularPharmaceutics2018,15(9),3767-3776

[8]YanpingCao,ZhihaoWei,MengmengLi,HaiyanWang,LiYin,DongxiaoChen,YanfeiWang,YongchaoChen,QiYuan,XiaohuiPu*,LanlanZong*,ShaofengDuan*.Formulation,pharmacokineticevaluationandcytotoxicityofanenhanced-penetrationpaclitaxelnanosuspension.CurrentCancerDrugTargets201919(4),338-347

[9]Pu,Xiaohui;Li,Jia;Qiao,Peng;Li,Mengmeng;Wang,Haiyan;Zong,Lanlan;Yuan,Qi;Duan,Shaofeng*.MesoporousSilicaNanoparticlesasaProspectiveandPromisingApproachforDrugDeliveryandBiomedicalApplications.CurrentCancerDrugTargets2019,19(4),285-295

[10]WangDa-Yong;WangDa-Yong;HongYa;ChenYa-Ge;DongPeng-Zhen;LiuShi-Yu;GaoYing-Ran;LuDan;LiHui-Min;LiTao;Dong‐DongWu*;Xin-YingJi*；Shao-FengDuan*.PEST-containingnuclearproteinregulatescellproliferation,migration,andinvasioninlungadenocarcinoma.Oncogenesis2019,8(3),22

[11]Li,Changlin;He,Chenchen;Xu,Ying;Xu,Haixia;Tang,Yuzhe;Chavan,Hemantkumar;Duan,Shaofeng;Artigues,Antonio;Forrest,MarcusLaird;Krishnamurthy,Partha;etal.AlternoleliminatesexcessiveATPproductionbydisturbingKrebscycleinprostatecancer.Prostate2019,79(6),628-639

[12]Guo-YuZhang#,DanLu#,Shao-FengDuan#,Ying-RanGao,Shi-YuLiu,YaHongPeng-ZhenDong,Ya-GeChen,TaoLi,Da-YongWang,Xiang-ShuCheng,FeiHeJian-SheWei,Guang-YuLi,Qing-YongZhang,Dong-DongWu.HydrogenSulfideAlleviatesLipopolysaccharide-InducedDiaphragmDysfunctioninRatsbyReducingApoptosisandInflammationthroughROS/MAPKandTLR4/NF-κBSignalingPathways.OxidativeMedicineandCellularLongevity2018,2018,9647809

[13]DongdongWu,HonggangWang,TieshanTengShaofengDuan,AilingJi,YanzhangLi.Hydrogensulfideandautophagy:Adoubleedgedsword.PharmacologicalResearch2018,131,120-127

[14]Huang,Shengnan;Liu,Ying;Xu,Xin;Ji,Mengfei;Li,Yuanmin;Song,Chengjun;Duan,Shaofeng*;Hu,Yurong*.TripletherapyofhepatocellularcarcinomawithmicroRNA-122anddoxorubicinco-loadedfunctionalizedgoldnanocages.JournalofMaterialsChemistryB:MaterialsforBiologyandMedicine2018,6(15),2217-2229

[15]MengfeiJi,XiaojingQiu,LinHou,YuanminLi,ShengnanHuang,YangLiu,ShaofengDuan*,YurongHu*.ConstructionandApplicationofaLiverCancer-targetingdrugDeliverySystemBasedonCore-shellGoldNanocages.InternationalJournalofNanomedicine2018,13,1773-1789

[16]ShijinBao,ShengnanHuang,YingLiu,YurongHu,*WeipingWang,MengfeiJi,HuiliLi,NingxiaZhang,ChengzhiSong,ShaofengDuan*.Goldnanocageswithdualmodalityforimageguidedtherapeutics.Nanoscale2017,9,7284-7296

[17]Li,Mengmeng;Chen,Yongchao;Yin,Li;Wang,Haiyan;Cao,Yanping;Wei,Zhihao;Wang,Yanfei;Yuan,Qi;Pu,Xiaohui;Zong,Lanlan;Duan,Shaofeng.Formulationandstabilityevaluationofstructure-alteredpaclitaxelnanosuspensionsstabilizedbyabiocompatibleaminoacidcopolymer.ScienceofAdvancedMaterials2017,9(10),1713-1723

[18]ChenchenHe,ShaofengDuan,LiangDong,YifenWang,QingtingHu,ChunjingLiu,MarcusL.Forrest,JeffreyM.Holzbeierlein,SuxiaHan,BenyiLi.Characterizationofanovelp110β-specificinhibitorBL140thatovercomesMDV3100-resistanceincastration-resistantprostatecancercells.Prostate2017,77(11):1187-1198.

[19]ShengnanHuang,ChunmingLi,WeipingWang,HuanjieLi,ZhiSun,ChengzhiSong,ShaofengDuan*,YurongHu*,BenyiLi.A54peptide-mediatedfunctionalizedgoldnanocagesfortargeteddeliveryofDOXasacombinationalchemo-photothermaltherapyforhepatocellularcarcinoma.InternationalJournalofNanomedicine2017,12,5163-5176

[20]ShengnanHuang#,ShaofengDuan#,JingWang,ShijinBao,XiaojingQiu,ChunmingLi,YingLiu,LijuanYan,ZhenzhongZhang,YurongHu.FolicAcidMediatedFunctionalizedGoldNanocagesforTargetedDeliveryofAnti-miR-181binCombinationofGeneTherapyandPhotothermalTherapyagainstHepatocellularCarcinoma.AdvancedFunctionalMaterials2016,26(15),2532-2544(firstco-author)

[21]SolomonZOkbazghi,ApurvaSMore,DerekRWhite,ShaofengDuan,IshanSShah,SangeetaBJoshi,CRussellMiddaugh,DavidBVolkin,ThomasJTolbert.Production,Characterization,andBiologicalEvaluationofWell-DefinedIgG1FcGlycoformsasaModelSystemforBiosimilarityAnalysis.JPharmSci2016,105(2),559-74.

[22]YunqiZhao,TiZhang#,ShaofengDuan#,NealMDavies,MLairdForrest.CD44-tropicpolymericnanocarrierforbreastcancertargetedrapamycinchemotherapy.Nanomedicine2014,10(6),1221-30.

[23]Lohrman,Jessica;Liu,Yueying;Duan,Shaofeng;Zhao,Xiaoyong;Wuttig,Manfred;Ren,Shenqiang;AllConjugatedCopolymerExcitonicMultiferroics.AdvancedMaterials2013,25(5),783-787.

[24]Ndolo,RosemaryA.;Luan,Yepeng;Duan,Shaofeng;Forrest,M.Laird;Krise,JeffreyP.Lysosomotropicpropertiesofweaklybasicanticanceragentspromotecancercellselectivityinvitro.PLoSOne2012,7(11),e49366.

[25]SMCohen,RMukerji,SDuan,SCai,MLForrest,MSCohenM.LairdForrest.ANovelNanocarrierDeliverySystemforDoxorubicinwithImprovedTumorResponseandReducedSystemicToxicityinAdvancedPediatricNon-HodgkinLymphoma.JournalofSurgicalResearch.2012,172(2),317.

[26]YunqiZhao#,ShaofengDuan#,XingZeng,ChunjingLiu,BenyiLi,NealM.Davies,MLairdForrest.ProdrugStrategyforPSMA-targettedDeliveryofTGX-221toProstateCancerCells.MolecularPharmaceutics2012,9,17051716(firstco-author).

[27]TarynR.Bagby#,ShaofengDuan#,ShuangCai,LairdForrest.Functionallymphaticimagingusingnegativelychargedstarpolymerarchitecturesgraftedwithnear-infrareddye.EuropeanJournalofPharmaceuticalSciences2012,47(1),287-294(firstco-author)

[28]TarynR.Bagby,ShuangCai,ShaofengDuan,SharadviThati,Aires,DanielJ.,LairdForrest.Impactofmolecularweightonlymphaticdrainageofabiopolymer-basedimagingagent.Pharmaceutics2012,4(2),276-295.

[29]ShaofengDuan,ShuangCai,YumeiXie,M.LairdForrest.Esterstarpolymersascontrolleddrugreleasecarriersforcisplatinandnitricoxide.JournalofPolymerSciencePartA:PolymerChemistry2012,50,2715–2724.

[30]ShaofengDuan,ShuangCai,QiuhongYang,M.LairdForrest.Multi-armpolymericnanocarrierasanitricoxidedeliveryplatformforchemotherapyofheadandnecksquamouscellcarcinoma.Biomaterials2012,33,3243-3253.

[31]YepengLuan,QiuhongYang,YumeiXie,ShaofengDuan,M.LForrest.ASensitiveNear-InfraredFluorescentProbeforCaspase-mediatedApoptosis:SynthesisandApplicationinCellImaging.DrugDiscoveries&Therapeutics2011,5(5),220-226.

[32]RajeshKumarPatti,ShaofengDuan,ZhipengWang,JamesW.Herndon.PreparationofphenalenesandhydronaphthacenesthroughtandemalkyneFischer–carbenecomplexcouplingandinter-orintra-molecularDiels–Alderreactions.TetrahedronLett.2011,52(32),4182-4185.

[33]RajeshKumar-Patti,ShaofengDuan,AlejandroCamacho-Davila,KrisWaynant,KennethADunn,JamesWHerndon.SynthesisofhydronaphthalenesthroughcouplingofenynecarbonylcompoundsthatcontainpendantalkenegroupswithFischercarbenecomplexes.TetrahedronLett.2010,51(28),3682-3684.

[34]Xie,Yumei;Duan,Shaofeng;Forrest,M.Laird.Alkyne-and1,6-elimination-succinimidylcarbonate-terminatedheterobifunctionalpoly(ethyleneglycol)forreversible"click"PEGylation.DrugDiscoveries&Therapeutics2010,4(4),240-245.

[35]SandipanSinha,LeiZhang,ShaofengDuan,ToddWilliams,JosefVlasak,RoxanaLonescu,ElizabethTopp.EffectofproteinstructureondeamidationrateintheFcfragmentofanIgG1monoclonalantibody.ProteinScience2009,18(8),1573-1584.

[36]ShaofengDuan,RanjanJana,JonTunge.“Lewisacid-catalyzeddiastereoselectivehydroarylationofbenzylidenemalonicesters”J.Org.Chem.2009,74,4612–4614.

[37]ShaofengDuan,DilipK.Sinha-Mahapatra,JamesW.Herndon.“SynthesisofNanphthalenesthroughthree-componentcouplingofalkynes,FischercarbenecomplexesandBenzaldehydeHydrozonesviaIsoindoleintermediates”Org.Lett.2008,10,1541-1544.

[38]ShaofengDuan,KarenCress,KrisWaynant,EliasRamos-Miranda,JamesW.Herndon.“Synthesisofalkylidenephthalansthroughfluoride-inducedcyclizationofelectron-deficient2-siloxymethylphenylacetylenederivatives”Tetrahedron2007,63,2959-2965.

[39]BinayK.Ghorai,ShaofengDuan,Delujiang,JamesW.Herndon.“Couplingofβ-Cyanocarbene-ChromiumComplexeswith2-AlkynylbenzoylDerivatives:A(5+5)-CycloadditionApproachtoPhenanthridines”Synthesis2006,21,3661-3669.