研究领域
涉及结构生物学、生物物理化学以及药物设计领域。
近期论文
"Conformational transition pathway in the allosteric process of human glucokinase", Zhang J, Li C, Chen K, Zhu W, Shen X*, Jiang HL*, Proc Natl Acad Sci USA.2006,103,13368-73.
"Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations", Chen S, Hu T, Zhang J, Chen J, Chen K, Ding J, Jiang HL, Shen X*, J Biol Chem. 2008, 283, 554-564.
“The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis”, Hu T, Wu D, Chen J, Ding J, Jiang H*, Shen X*. J Biol Chem. 2008, 283, 21284-93.
"Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)", Zhang L, Liu W, Hu T, Du L, Luo C, Chen K, Shen X*, Jiang HL*,J Biol Chem. 2008, 283, 5370-5379.
"Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations", Chen S, Chen L, Tan J, Chen J, Du L, Sun T, Shen J, Chen K, Jiang HL*, Shen X*, J Biol Chem. 2005, 280, 164-173.
"Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro", Chen L, Gui C, Luo X, Yang Q, Günther S*, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K, Shen J, Shen X*, Jiang HL, J. Virol. 2005, 79, 7095-7103.
"Virtual screening on natural products for discovering active compounds and target information", Shen J, Xu X, Cheng F, Liu H, Luo X, Shen J, Chen K, Zhao W, Shen X*, Jiang HL*, Curr Med Chem. 2003, 10, 2327-42.
"An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development", Chen S, Luo H, Chen L, Chen J, Shen J, Zhu W, Chen K, Shen X*, Jiang HL*, Curr Pharm Des. 2006, 12, 4539-4553.
"Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction", Luo H, Wu D, Shen C, Chen K, Shen X*, Jiang HL, Int J Biochem Cell Biol. 2006, 38, 589-599.
"Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma", Zou G, Gao Z, Wang J, Zhang Y, Ding H, Huang J, Chen L, Guo Y, Jiang H, Shen X*, Biochem Pharmacol. 2008, 75, 1381-1392.