曹鹏秀，博士

河北师范大学“精英计划”引进人才

河北省第八批“百人计划”省级特聘专家主要学习和工作经历:

1998-2002河北师范大学生命科学学院获得理学学士学位

2002-2007中国科学院遗传与发育生物学研究所获得理学博士学位

2008-2017美国CaseWesternReserveUniversity、Cleveland

Clinic和UniversityofMichigan等高校或研究所进行博士后研究

2018-今河北师范大学讲师

主要教学科研工作:

教学:担任国家级精品资源共享课《组织学与解剖学》主讲教师。主讲课程：《组织学与解剖学》、《组织学与解剖学实验》和《生物信息学》。

研究方向：(1)铁代谢影响肺纤维化进程分子机制研究及有效治疗策略和药物的开发及筛选；(2)雾霾引起肺部重塑的机制研究和干预策略；(3)吸烟致肺部疾病机制研究及分子治疗策略。

1.CaoPengxiu*,AokiYoshiro*,BadriLinda,WalkerNatalieM.,ManningCaseyM.,LagsteinAmir,FearonEricR.,LamaVibhaN.(2017)Autocrinelysophosphatidicacidsignalingactivatesβ-cateninandpromoteslungallograftfibrosis.JournalofClinicalInvestigation,127(4):1517-1530.*Contributeequally.

2.ChenShenghan,CaoPengxiu,DongNingzheng,PengJianhao,ZhangChunyi,WangHao,ZhouTiantian,YangJunhua,ZhangYue,MartelliElizabethE.,PrasadSathyamanglaV.Naga,MillerRachelE.,MalfaitAnne-Marie,ZhouYiqing,WuQingyu.(2015)PCSK6-mediatedcorinactivationisessentialfornormalbloodpressure.NatureMedicine,21(9):1048-1053.

3.CaoPengxiu*,SunWenyu*,KrampKristopher,ZhengMaohua,SalomDavid,JastrzebskaBeata,JinHui,PalczewskiKrzysztof,FengZhaoyang.(2012)Light-sensitivecouplingofrhodopsinandmelanopsintoGi/oandGqsignaltransductioninCaenorhabditiselegans.FASEBJ.,26(2):480-491.*Contributeequally.

4.SalomDavid*,CaoPengxiu*,SunWenyu*,KrampKristopher,JastrzebskaBeata,JinHui,FengZhaoyang,PalczewskiKrzysztof.(2012)HeterologousexpressionoffunctionalG-protein-coupledreceptorsinCaenorhabditis.FASEBJ.,26(2):492-502.*Contributeequally.

5.CaoPengxiu*,YuanYiyuan*,PehekElizabethA.,MoiseAlexR.,HuangYing,PalczewskiKrzysztof,FengZhaoyang.(2010)Alpha-synucleindisrupteddopaminehomeostasisleadstodopaminergicneurondegenerationinCaenorhabditiselegans.PLoSONE,5(2),e9312.doi:10.1371/journal.pone.0009312.*Contributeequally.

6.CaoPengxiu,SongJian,ZhouChunjiang,WengManli,LiuJing,WangFuxin,ZhaoFeng,FengDianqi,WangBin.(2009)CharacterizationofmultiplecoldinducedgenesfromAmmopiptanthusmongolicusandfunctionalanalysesofgeneAmEBP1.PlantMolecularBiology,69(5),529-539.

7.FeiY.B.*,CaoP.X.*,GaoS.Q.,WangB.,WeiL.B.,ZhaoJ.,ChenG.&WangB.H.(2008)Purificationandanalysisofantifreezeproteinsfromaligneousplant.PreparativeBiochemistryandBiotechnology,38(2),172-183.*Contributeequally.

8.FeiY.B.*,CaoP.X.*,GaoS.Q.,WeiL.B.&WangB.(2005)Discoveryofahomologofsiderophilininaplant.JournalofIntegrativePlantBiology,47(12),1409-1411.*Contributeequally.

9.ChenYuanyuan,JastrzebskaBeata,CaoPengxiu,ZhangJianye,WangBenlian,SunWenyu,YuanYiyuan,FengZhaoyang,PalczewskiKrzysztof.(2014)InherentinstabilityoftheretinitispigmentosaP23Hmutantopsin.TheJournalofBiologicalChemistry,289(13):9288-9303.

10.YuanYiyuan,HakimiParvin,KaoClara,KaoAllison,LiuRuifu,JanochaAllison,Boyd-TresslerAndrea,HangXi,AlhoraibiHanna,SlaterErin,XiaKevin,CaoPengxiu,ShueQuinn,ChingTsui-Ting,HsuAo-Lin,ErzurumSerpilC.,DubyakGeorgeR.,BergerNathanA.,HansonRichardW.,FengZhaoyang.(2016)ReciprocalChangesinPhosphoenolpyruvateCarboxykinaseandPyruvateKinasewithAgeAreaDeterminantofAginginCaenorhabditiselegans.TheJournalofBiologicalChemistry,291(3):1307-1319.

11.YuanYiyuan,CaoPengxiu,SmithMarkA.,KrampKristopher,HuangYing,HisamotoNaoki,MatsumotoKunihiro,HatzoglouMaria,JinHui,FengZhaoyang.(2011)DysregulatedLRRK2/p38signalinginresponsetoendoplasmicreticulumstressleadstodopaminergicneurondegeneration.PLoSONE,6(8):e22354.

12.SalomDavid,CaoPengxiu,YuanYiyuan,MiyagiMasaru,FengZhaoyang,PalczewskiKrzysztof.(2015)IsotopiclabelingofmammalianGPCRsheterologouslyexpressedinCaenorhabditiselegans.AcceptedinAnalBiochem.,2015,472:30-36.

13.ZhengMaohua,CaoPengxiu,YangJiong,XuX.Z.Shawn,FengZhaoyang.(2012)CalciumimagingofmultipleneuronsinfreelybehavingC.elegans.JournalofNeuroscienceMethods.206(1),78–82.

14.JastrzebskaBeata,SalomDavid,JinHui,CaoPengxiu,SunWenyu,PalczewskiKrzysztof,FengZhaoyang.(2013)ExpressionofmammalianGprotein-coupledreceptorsinCaenorhabditiselegans.MethodsinEnzymology.520:239-256.

15.ZhouChunjiang,ChenCuixia,CaoPengxiu,WuSuowei,SunJianwei,JinDemin,WangBin.(2007).CharacterizationandfinemappingofRppQ,aresistancegenetosoutherncornrustinmaize.MolecularGeneticsandGenomics,278(6),723-728.

16.SongJian,LiuJing,WengManli,HuangYanyan,LuoLei,CaoPengxiu,SunHaiwei,LiuJie,ZhaoJinhong,FengDianqi,WangBin.(2013)CloningofGalactinolSynthaseGenefromAmmopiptanthusMongolicusanditsexpressionintransgenicPhotiniaserrulataplants.Gene.15,513(1):118-127.

17.LiangF.,KongF.,ZhouC.,CaoP.,YeC.&WangB.(2005)Cloningandcharacterizationofanon-TIR-NBS-LRRtypediseaseresistancegeneanaloguefrompeach.DNASequence,16(2),103-110.

18.BaiL.,YeC.,LuJ.,YangD.,XueH.,PanY.,CaoP.,WangB.,&LiuM.(2009)IptgenetransformationinpetuniabyanAgrobacteriummediatedmethod.JournalofImmunoassayandImmunochemistry,30(2):224-31.