EDUCATION 2000 – 2004 B.Sc., Chemistry, Peking University 2004 – 2009 Ph.D., Chemistry, The University of Hong Kong PROFESSIONAL EXPERIENCE 2010 – 2011 Research Associate, The University of Hong Kong 2012 – 2016 Postdoctoral Fellow, The Rockefeller University, USA 2016 – present Associate Professor, Peking University, Shenzhen Graduate School

Our group’s research interests mainly lie in the field of Chemical Biology, focusing on the development and application of chemical probes, in combination with cutting-edge proteomics and traditional biology methods, to understand the molecular and cellular mechanisms of biological processes, especially the pathological processes of human diseases, for the identification of novel therapeutic targets and drugs.

Sun, Y.#; Chen, Y.#; Xu, Y.; Zhang, Y.; Lu, M.; Li, M.; Zhou, L.; Peng, T.* Genetic Encoding of ε-N-L-Lactyllysine for Detecting Delactylase Activity in Living Cells. Chem. Commun. 2022, 58, 8544-8547. Link. Sun, Y.#; Chen, Y.#; Peng, T.* A Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation. Chem. Sci. 2022, 13, 6019-6027. Link. Yao, L.; Rong, Y.; Ma, X.; Li, H.; Deng, D.; Chen, Y.; Yang, S.; Peng, T.; Ye, T.; Liang, F.; Xu, N.; Zhou, Q.* Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons. J. Neurosci. 2022, 42, 3066-3079. Link. Zhang, D.#; Lu, M.#; Chen, C.; Xu, Y.; Peng, T.* Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. ChemBioChem 2022, 23, e202100628. Link. Du, Y.#; Zhang, Y.#; Huang, M.#; Wang, S.; Wang, J.; Liao, K.; Wu, X.; Zhou, Q.; Zhang, X.; Wu, Y.-D.*; Peng, T.* Systematic Investigation of the aza-Cope Reaction for Fluorescence Imaging of Formaldehyde in Vitro and in Vivo. Chem. Sci. 2021, 12, 13857-13869. Link. Garst, E. H.; Lee, H.; Das, T.; Bhattacharya, S.; Percher, A.; Wiewiora, R.; Witte, I. P.; Li, Y.; Peng, T.; Im, W.; Hang, H. C*. Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity. ACS Chem. Biol. 2021, 16, 844-856. Link. Wang, S.#; Wu, X.#; Zhang, Y.; Zhang, D.; Xie, B.; Pan, Z.; Ouyang, K.; Peng, T.* Discovery of a Highly Efficient Nitroaryl Group for Detection of Nitroreductase and Imaging of Hypoxic Tumor Cells. Org. Biomol. Chem. 2021, 19, 3469-3478. Link. Li, Y.#; Wang, S.#; Chen, Y.; Li, M.; Dong, X.; Hang, H. C.*; Peng, T.* Site-Specific Chemical Fatty-Acylation for Gain-of-Function Analysis of Protein S-Palmitoylation in Live Cells. Chem. Commun. 2020, 56, 13880-13883. Link. Chen, C.; Peng, T.* Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells. STAR Protocols 2020, 1, 100109. Link. Zhang, Y.#; Du, Y.#; Li, M.; Zhang, D.; Xiang, Z.; Peng, T.* Activity-Based Genetically Encoded Fluorescent and Luminescent Probes for Detecting Formaldehyde in Living Cells. Angew. Chem. Int. Ed. 2020, 59, 16352-16356. Link. Wu, X.; Spence, J. S.; Das, T.; Yuan, X.; Chen, C.; Zhang, Y.; Li, Y.; Sun, Y.; Chandran, K.; Hang, H. C.*; Peng, T.* Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase. Cell Chem. Biol. 2020, 27, 571-585.e576. Link. Zhang, Z. J.; Pedicord, V. A.; Peng, T.; Hang, H. C.* Site-Specific Acylation of a Bacterial Virulence Regulator Attenuates Infection. Nat. Chem. Biol. 2020, 16, 95-103. Link. Spence, J. S.#; He, R.#; Hoffmann, H.-H.; Das, T.; Thinon, E.; Rice, C. M.; Peng, T.*; Chandran, K.*; Hang, H. C.* IFITM3 Directly Engages and Shuttles Incoming Virus Particles to Lysosomes. Nat. Chem. Biol. 2019, 15, 259-268. Link. Peng, T.*; Hang, H. C.*: Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens. In Activity-Based Protein Profiling; Cravatt, B. F., Hsu, K.-L., Weerapana, E., Eds.; Springer International Publishing: Cham, 2019; pp 93-110. Link. Liu, W.#; Zhou, Y.#; Peng, T.#; Zhou, P.; Ding, X.; Li, Z.; Zhong, H.; Xu, Y.; Chen, S.; Hang, H. C.*; Shao, F.* Nε-Fatty Acylation of Multiple Membrane-associated Proteins by Shigella IcsB Effector to Modulate Host Function. Nat. Microbiol. 2018, 3, 996-1009. Link. Peng, T.*; Hang, H. C.* Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. J. Am. Chem. Soc. 2016, 138, 14423-14433.